kerafast總代理靶點科(ke)技(ji)貨(huo)號EB0011單克隆抗體(ti)Anti-VSV-M [23H12] Antibody與VSV-M蛋白反應。

產品特色：

-與VSV-M蛋白發生(sheng)反應

-適用(yong)于蛋(dan)白質(zhi)印跡應用(yong)

背(bei)景(jing)介紹：

水皰性口炎病(bing)毒(du)（VSV）是一種(zhong)經過(guo)充分研究的(de)包膜(mo)負鏈RNA病(bing)毒(du)。VSV 基因組編碼 5 種(zhong)蛋白(bai)(bai)質(zhi)：N、P、M、G 和(he) L。G蛋白(bai)(bai)（糖蛋白(bai)(bai)）位于病(bing)毒(du)粒子表面，負責病(bing)毒(du)附著和(he)滲(shen)透。此外(wai)，許多(duo)慢靜(jing)脈(mo)載體(ti)是用來自印(yin)第(di)安(an)納州血清型(xing)的(de)VSV-G假分型(xing)的(de)。

水皰性(xing)口炎病(bing)毒（VSV）是一種經過(guo)充分(fen)研究的(de)包(bao)膜負(fu)鏈RNA病(bing)毒。VSV 基因(yin)組(zu)(zu)編碼(ma) 5 種蛋(dan)(dan)白(bai)(bai)質：N、P、M、G 和 L。M蛋(dan)(dan)白(bai)(bai)（或基質蛋(dan)(dan)白(bai)(bai)）負(fu)責(ze)結合核衣殼并將其凝聚成緊密盤繞的(de)螺旋，并將核衣殼與包(bao)膜結合。M蛋(dan)(dan)白(bai)(bai)的(de)這(zhe)種活(huo)性(xing)使(shi)病(bing)毒具有彈狀的(de)形狀。除(chu)了M蛋(dan)(dan)白(bai)(bai)在病(bing)毒組(zu)(zu)裝中的(de)作用外，它還(huan)負(fu)責(ze)介導VSV發病(bing)機(ji)制的(de)分(fen)子機(ji)制。野生M型蛋(dan)(dan)白(bai)(bai)抑制感(gan)染細(xi)胞中的(de)宿主基因(yin)表達(da)并抑制抗病(bing)毒反應。

Background：

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

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